Sandbox GGC5
Titin
This is a default text for your page Sandbox GGC5. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. FunctionTitin is a key component in the assembly and function of vertebrate striated muscles. Titin provides connections at the level of individual micro-filaments and contributes to the fine balance of forces between the two halves of the sarcomere. In non-muscle cells, titin plays a role in chromosome condensation and chromosome segregation during mitosis. On the cellular level, titin is typically located within the nucleus of the cell; however, it can also be located within the cytoplasm. DiseaseRelevanceStructural highlightsThis is the rainbow version of the titin molecule. This structure is colored to differentiate each chain, starting with the blue 5' amino end, ending with the red 3' carboxyl end. This secondary structure of titin highlights the Polar. sections of the titin molecule. In this representation, Polar sections of titin are shaded in purple and hydrophobic regions are shaded in grey. The central beta-sandwich structure of the molecule encloses a well defined hydrophobic core. This helps to stabilize the molecule that contains no disulfide bridges and rely solely on hydrogen bonding in the side chains and backbone. This is the complete titin structure. This secondary view shows multiple titin proteins connected together. This representation is known as the titin band.
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