5xk0 | pdb_00005xk0

Structure of 8-mer DNA2

spinqualitylabelsall models 5xk0, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xk0 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, Ag(I) is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-Ag(I) -C pairs and the first reported G-Ag(I) -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these Ag(I) -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between Ag(I) and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices. A DNA Structure Containing Ag(I) -Mediated G:G and C:C Base Pairs.,Liu H, Shen F, Haruehanroengra P, Yao Q, Cheng Y, Chen Y, Yang C, Zhang J, Wu B, Luo Q, Cui R, Li J, Ma J, Sheng J, Gan J Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9430-9434. doi: 10.1002/anie.201704891., Epub 2017 Jul 7. PMID:28635152 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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