Rac

spinqualitylabelsall models Human Rac1 (magenta) complex with YpkA (cyan), GDP and Mg+2 ion (green) (PDB code 2h7v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The small G-protein Rac or Ras-related C3 botulinum toxin substrate. Rac1 is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes. Rac3 binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. Disease Mutations in Rac2 are associated with neutrophil immunodeficiency syndrome. Structural highlights The interactions between Rac1 and YpkA are via switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA. GDP binding site on Rac1. 3D structures of Rac Rac 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman