6vv5 | pdb_00006vv5

Cryo-EM structure of porcine epidemic diarrhea virus (PEDV) spike protein

Loading... Status: waiting for Mol* initialization Structural highlights 6vv5 is a 3 chain structure with sequence from Pedv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BMA, NAG, PAM, MAN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [S5RJN4_9ALPC] S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200] See Also Sandbox 3001 Spike protein

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