Sandbox GGC3
Spike glycoprotein
This is a default text for your page Sandbox GGC3. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. FunctionSARS-Cov-2 utilizes the S-protein to facilitate attachment to host cell surface membranes. DiseaseThis protein is related to the SARS-cov-2 RelevanceThe S-protein of SARS-CoV-2 expressed by the ORF1b gene is trimeric in structure, where each monomer is 180 kDa in size and has two main subunits, an S1 and an S2 subunit. S1 subunit attaches itself to the host cell angiotensin-converting enzyme 2 (ACE2) transmembrane protein. S2 subunit acts in the fusion process of the S-protein which is done by the cleavage protease transmembrane serine or furin <ref>Mohammad, A., Alshawaf, E., Marafie, S. K., Abu-Farha, M., Abubaker, J., & Al-Mulla, F. (2020). Higher binding affinity of Furin to SARS-CoV-2 spike (S) protein D614G could be associated with higher SARS-CoV-2 infectivity. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, S1201-9712(20)32237-2. Advance online publication. https://doi.org/10.1016/j.ijid.2020.10.033
Structural highlightsThis is a sample scene created with SAT to Secondary structure ">color</scene> by Group, and another to make 5 prime to 3 prime end ">a transparent representation</scene> of the protein. Carbohydrate and ligainds</scene> You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. Val367Binding region val367 . D614 The Mutation site D614
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