Sandbox GGC3

Spike glycoprotein

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is the 3D structure representation of the Spike glycoprotein . Function SARS-Cov-2 utilizes the S-protein to facilitate attachment to host cell surface membranes. Disease This protein is related to the SARS-cov-2 Relevance The S-protein of SARS-CoV-2 expressed by the ORF1b gene is trimeric in structure, where each monomer is 180 kDa in size and has two main subunits, an S1 and an S2 subunit. S1 subunit attaches itself to the host cell angiotensin-converting enzyme 2 (ACE2) transmembrane protein. S2 subunit acts in the fusion process of the S-protein which is done by the cleavage protease transmembrane serine or furin <ref>Mohammad, A., Alshawaf, E., Marafie, S. K., Abu-Farha, M., Abubaker, J., & Al-Mulla, F. (2020). Higher binding affinity of Furin to SARS-CoV-2 spike (S) protein D614G could be associated with higher SARS-CoV-2 infectivity. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, S1201-9712(20)32237-2. Advance online publication. https://doi.org/10.1016/j.ijid.2020.10.033 Structural highlights This is a sample scene created with SAT to NTD -CTS1 subunit is in the downstream of NTD and S2 subunit is in the upsteam of CT. Val367Binding region val367 . D614 The Mutation site D614 . LYS 187 The Receptor Binding Protein Site (RBP)