1jjv | pdb_00001jjv

DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP

spinqualitylabelsall models 1jjv, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1jjv is a 1 chain structure with sequence from "bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ATP, HG, SO4 Gene: YacE ("Bacterium influenzae" Lehmann and Neumann 1896) Activity: Dephospho-CoA kinase, with EC number 2.7.1.24 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [COAE_HAEIN] Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Dephospho-coenzyme A kinase catalyzes the final step in CoA biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. The protein from Haemophilus influenzae was cloned and expressed, and its crystal structure was determined at 2.0-A resolution in complex with ATP. The protein molecule consists of three domains: the canonical nucleotide-binding domain with a five-stranded parallel beta-sheet, the substrate-binding alpha-helical domain, and the lid domain formed by a pair of alpha-helices. The overall topology of the protein resembles the structures of nucleotide kinases. ATP binds in the P-loop in a manner observed in other kinases. The CoA-binding site is located at the interface of all three domains. The double-pocket structure of the substrate-binding site is unusual for nucleotide kinases. Amino acid residues implicated in substrate binding and catalysis have been identified. The structure analysis suggests large domain movements during the catalytic cycle. Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae.,Obmolova G, Teplyakov A, Bonander N, Eisenstein E, Howard AJ, Gilliland GL J Struct Biol. 2001 Nov;136(2):119-25. PMID:11886213 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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