2n87 | pdb_00002n87

Solution structure of the PPIase domain of TbPar42

spinqualitylabelsall models 2n87, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n87 is a 1 chain structure with sequence from Tryb2. This structure supersedes the now removed PDB entry 2mnt. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2n84 Gene: Tb927.7.2480 (TRYB2) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Trypanosoma brucei is a unicellular eukaryotic parasite, which causes the African sleeping sickness in humans. The recently discovered trypanosomal protein Parvulin 42 (TbPar42) plays a key role in parasite cell proliferation. Homologues of this two-domain protein are exclusively found in protozoa species. TbPar42 exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Using NMR and X-ray analysis as well as activity assays, we report on the structures of the single domains of TbPar42, discuss their intra-molecular interplay, and give some initial hints as to potential cellular functions of the protein. Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei.,Rehic E, Hoenig D, Kamba BE, Goehring A, Hofmann E, Gasper R, Matena A, Bayer P Biomolecules. 2019 Mar 7;9(3). pii: biom9030093. doi: 10.3390/biom9030093. PMID:30866577 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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