6uzj | pdb_00006uzj

NMR structure of the HACS1 SH3 domain

spinqualitylabelsall models 6uzj, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6uzj is a 1 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 2kea. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2ebp Gene: SAMSN1, HACS1 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SAMN1_HUMAN] Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).

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