Structural highlights
7cxz is a 1 chain structure with sequence from Arath. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | FE, NI, TRS |
| Gene: | PCO2, At5g39890, MYH19.8 (ARATH) |
| Activity: | Cysteine dioxygenase, with EC number 1.13.11.20 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[PCO2_ARATH] Oxidizes N-terminal cysteine residues, thus preparing the protein for N-end rule pathway-mediated proteasomal degradation. Controls the preparation of ERF-VII proteins for degradation via the 26S proteasome. Not active on Cys located inside or at the C-terminus of a peptide. Represses the anaerobic response.[1]
References
- ↑ Weits DA, Giuntoli B, Kosmacz M, Parlanti S, Hubberten HM, Riegler H, Hoefgen R, Perata P, van Dongen JT, Licausi F. Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway. Nat Commun. 2014 Mar 6;5:3425. doi: 10.1038/ncomms4425. PMID:24599061 doi:https://dx.doi.org/10.1038/ncomms4425