1tpy | pdb_00001tpy

Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis

spinqualitylabelsall models 1tpy, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1tpy is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 16A, CO3, SAH Gene: mmaA2 ("Bacillus tuberculosis" (Zopf 1883) Klein 1884) Activity: Cyclopropane-fatty-acyl-phospholipid synthase, with EC number 2.1.1.79 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [MMAA2_MYCTU] Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also catalyzes the biosynthesis of the cis-cyclopropanated methoxymycolates. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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