Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of isopentenyl diphosphate (IPP) and produce linear polyprenyl diphosphate. The length of this isoprenoid carbon chain varies from short molecules like geranyl diphosphate (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein N-glycosylation. It synthesises the precursor of glycosyl carrier dolichol-phosphate. Mutations in gens coding for hcis-PT can cause severe diseases, such as retinitis pigmentosa. ContentsStructureThe hcis-PT subunitsThe active site organizationCatalytical activity of the human cis-prenyltransferasesThe elongation reaction in the hydrophobic active-site tunnelRegulation of the product lengthImportance of the enzymeProduct of the N-glycosilationDisease comprehensionStructural highlightsThis is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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This page was last modified 22:23, 12 January 2021.