6zs8 | pdb_00006zs8

X-ray structure of the adduct formed upon treating lysozyme with an aged solution of arsenoplatin-1

spinqualitylabelsall models 6zs8, resolution 2.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6zs8 is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: A6R, DMS, EDO, NA, NO3 Activity: Lysozyme, with EC number 3.2.1.17 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. Publication Abstract from PubMed Arsenoplatin-1 (AP-1) is an innovative dual-action anticancer agent that contains a platinum(ii) center coordinated to an arsenous acid moiety. We found that AP-1 spontaneously aggregates in aqueous solutions generating oligomeric species of increasing length. Afterward, we succeeded in solving the crystal structure of the adduct formed between the model protein lysozyme and an early AP-1 oligomer that turned out to be a trimer. Remarkably, this crystal structure traps an early stage of AP-1 aggregation offering detailed insight into the molecular process of the oligomer's growth. The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct.,Ferraro G, Cirri D, Marzo T, Pratesi A, Messori L, Merlino A Dalton Trans. 2020 Dec 15. doi: 10.1039/d0dt04068a. PMID:33320144 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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