1dj8 | pdb_00001dj8
CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA
Overview
The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.
About this Structure
1DJ8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria., Gajiwala KS, Burley SK, J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:10623550 Page seeded by OCA on Fri May 2 13:54:33 2008
