Rabphilin

spinqualitylabelsall models Structure of glycosylated California poppy reticuline oxidase complex with reticuline and FAD (PDB code 3d2d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Rabphilin or berberine bridge-forming enzyme (RO) is part of the alkaloids biosynthesis pathway catalyzing the conversion of (S)-reticuline to (S)-scoulerine. RO catalyzes the cyclization of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon, C-8 of (S)- . Relevance Reticuline is a precursor of morphine and has potent central nervous system depressing effects. Structural highlights The 3D structure of the complex between RO and its substrate reticuline show the cofactor FAD having bicovalent attachment to RO His and Cys. The substrate reticuline is seen in the active site cavity interacting with FAD and numerous RO sidechains.

3D Structures of rabphilin 3-A

Updated on 02-February-2021

2cm5, 2cm6 – rRab C2B domain 541-680 – rat
3rbp – rRab C2B domain - NMR
5lo8 – rRab C2B domain + inositol phosphate derivative
5lob, 5low – rRab C2AB domain + SNAP25
2chd, 4lt7 – rRab C2A domain 378-510
4np9, 4ns0 – rRab C2A domain + inositol phosphate derivative
1zbd – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP
2k3h – mRab C2A domain 378-510 - mouse - NMR

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