Ubiquitin-fold modifier

spinqualitylabelsall models Chicken full-length metavinculin, 1st6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ubiquitin-fold modifier (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins. This attachment is called Ufmylation and requires Ubiquitin-like modifier activating enzyme (UBA5) and Umf1-conjugating enzyme (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER. Relevance Ufm1 participates in maintenance of homeostasis and protection from inflammatory disease. Structural highlights Vinculin Autoinhibition is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains (1st6). Energetically, I997 is key to maintaining this autoinhibition.

3D Structures of Ubiquitin-fold modifier

Updated on 03-February-2021

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• Ubiquitin-fold modifier
  • 1st6 – hUmf1 - human
    
  • 1wxs – hUmf1 - NMR
    
  • 5hkh – hUmf1 + peptide
    
  • 5iaa – hUmf1 + UBA5
    
  • 5l95 – hUmf1 + UBA5 + AMP
    
  • 6h77 – hUmf1 + UBA5 + ATP
    
  • 5xda – Umf1 + Umf1-specific protease - Caenorhabditis elegans
    
  • 6izg – Umf1 - Trypanosoma brucei - NMR
    
• Umf1-conjugating enzyme
  • 2z6o, 2z6p, 3evx – hUfc1
    
  • 2k07 – hUfc1 - NMR
    
• Ubiquitin-like modifier activating enzyme
  • 3h8v, 6h78 – hUBA5 + ATP
    
  • 3guc – hUBA5 + AMPPNP
    

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