2e1o | pdb_00002e1o

Solution structure of RSGI RUH-028, a homeobox domain from human cDNA

spinqualitylabelsall models 2e1o, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2e1o is a 1 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 1wqi. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: HHEX, HEX, PRH, PRHX (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Function [HHEX_HUMAN] Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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