1bvj | pdb_00001bvj

HIV-1 RNA A-RICH HAIRPIN LOOP

spinqualitylabelsall models 1bvj, 21 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1bvj is a 1 chain structure with sequence from Human immunodeficiency virus type 1 (mal isolate). Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription. HIV-1 A-rich RNA loop mimics the tRNA anticodon structure.,Puglisi EV, Puglisi JD Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:9846871 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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