2g7c | pdb_00002g7c

Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc

spinqualitylabelsall models 2g7c, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2g7c is a 2 chain structure with sequence from "bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, GAL, GLA, NAG Related: 2f6e Gene: toxA, tcdA ("Bacillus difficilis" Hall and O'Toole 1935) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TOXA_PEPDI] Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics. Carbohydrate recognition by Clostridium difficile toxin A.,Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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