2gdd | pdb_00002gdd

Human beta II tryptase with inhibitor CRA-27592

spinqualitylabelsall models 2gdd, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2gdd is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 5AM Gene: TPSB2, TPS2 (HUMAN) Activity: Tryptase, with EC number 3.4.21.59 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Tryptase

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