6l7q | pdb_00006l7q

Crystal structure of a hypothetical protein PYCH_01220 derived from Pyrococcus yayanosii

spinqualitylabelsall models 6l7q, resolution 1.16Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6l7q is a 1 chain structure with sequence from Pyryc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: PYCH_01220 (PYRYC) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We report the crystal structure of PYCH_01220, a hypothetical protein in Pyrococcus yayanosii CH1. This protein is composed of two domains, named Domain A and Domain B. While Domain B is not significantly homologous to known protein structures, Domain A is structurally analogous to the C-terminal ribonuclease domain of Escherichia coli colicin D. Domain A has a positively charged surface patch rendered by 13 basic residues, eight arginine or lysine residues of which are evolutionarily conserved. Electrophoretic mobility shift assays showed that PYCH_01220 binds to DNA, and charge-inversion mutations on this patch negatively affect the DNA binding, suggesting that the function of PYCH_01220 might involve nucleic acid-binding via the positively charged patch. This article is protected by copyright. All rights reserved. Crystal structure of PYCH_01220 from Pyrococcus yayanosii potentially involved in binding nucleic acid.,Noh H, Jeon JH, Kim YG, Oh BH Proteins. 2020 Nov 25. doi: 10.1002/prot.26029. PMID:33236809 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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