2i39 | pdb_00002i39

Crystal structure of Vaccinia virus N1L protein

spinqualitylabelsall models 2i39, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2i39 is a 6 chain structure with sequence from Vaccinia virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MPD Gene: N1L (VACWR028) (Vaccinia virus) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [N1_VACCC] Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses. Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.,Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also B-cell lymphoma proteins 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA