2ib1 is a 1 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
[NRADD_MOUSE] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Wang X, Shao Z, Zetoune FS, Zeidler MG, Gowrishankar K, Vincenz C. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. Cell Death Differ. 2003 May;10(5):580-91. PMID:12728256 doi:https://dx.doi.org/10.1038/sj.cdd.4401208
↑Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M, Schecterson LC. Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci. 2003 Jul 2;23(13):5425-36. PMID:12843241
↑Kim T, Hempstead BL. NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. EMBO J. 2009 Jun 3;28(11):1612-23. doi: 10.1038/emboj.2009.118. Epub 2009 Apr 30. PMID:19407813 doi:https://dx.doi.org/10.1038/emboj.2009.118
