2igb | pdb_00002igb

Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form

spinqualitylabelsall models 2igb, resolution 1.68Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2igb is a 2 chain structure with sequence from "bacillus_caldolyticus"_heinen_and_heinen_1972 "bacillus caldolyticus" heinen and heinen 1972. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, U5P Related: 1non, 1xz8, 1xzn, 1a3c Gene: pyrR ("Bacillus caldolyticus" Heinen and Heinen 1972) Activity: Uracil phosphoribosyltransferase, with EC number 2.4.2.9 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PYRR_BACCL] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable). Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Phosphoribosyltransferase 3D structures

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