2k9d | pdb_00002k9d

Solution structure of the domain X of measle phosphoprotein

spinqualitylabelsall models 2k9d, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2k9d is a 1 chain structure with sequence from Cell-associated subacute sclerosing panencephalitis. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: P/V (Cell-associated subacute sclerosing panencephalitis) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PHOSP_MEASE] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed In this paper we investigate the interaction between the C-terminal domains of the measles virus phosphoprotein (XD) and nucleoprotein (N(TAIL)) by using nuclear magnetic resonance chemical shift perturbation experiments. Using both N(TAIL) constructs and peptides, we show that contrary to the conserved Box2 region (N(489-506)), the C-terminal region of N(TAIL) (N(513-525)) does not directly interact with XD, and yet affects binding to XD. We tentatively propose a model where the C-terminus of N(TAIL) would stabilize the N(TAIL)-XD complex either via a functional coupling with N(489-506) or by reducing the entropic penalty associated to the binding-coupled-to-folding process. Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR.,Bernard C, Gely S, Bourhis JM, Morelli X, Longhi S, Darbon H FEBS Lett. 2009 Apr 2;583(7):1084-9. Epub 2009 Mar 9. PMID:19275899 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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