Sandbox GGC16

PU.1

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D PU.1 is a hematopoietic transcription factor. It specifically regulates transcription of genes specific to myeloid and lymphoid cells, ultimately leading to cellular differentiation. Name and Location The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence. Bases at Interface The protein resides in the nucleus. Binding Domain Residues at Binding Domain Ets binding domain is conserved across the Ets family of proteins. Binding domain is positively charged. Residues most closely interacting with DNA include Arginine and Lysine. Disease PU.1 has been identified as an oncogene. Mutations have been identified in patients with leukemias and lymphomas. Interestingly, the mutations are not always identified within the binding site. Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.