This is a default text for your page. Click above on edit this page to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
- Moving cargo usually from the center of the cell to the periphery.
- Involved in cell replication.
Disease
- Charcot Marie Tooth (CMT)
Relevance
Structural highlights
- Scene #1
- Kinesin structure is composed of eight anti-parallel B sheets surrounded by three alpha helices on either side Alpha-beta structure
- Scene #2
- This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination ATP-binding site
- Scene #3
- This is the Microtubule-binding site, where Kinesin binds to microtubules for stability MT-binding site
- Scene #4
- Charcot Marie Tooth is
This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:https://dx.doi.org/10.1002/ijch.201300024
- ↑ Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996 Apr 11;380(6574):550-5. PMID:8606779 doi:https://dx.doi.org/10.1038/380550a0