Sandbox GGC8

GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase)

spinqualitylabelsall models GAPDH Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is a default text for your page. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Function This Particular Protein Plays a big role in Glycolysis and activities in the nucleus. Glyceraldehyde-3-phosphate dehydrogenase is a very important enzyme that catalyzes the first step of the glycolysis pathway. This is done by converting D-glyceraldehyde-3-phosphate to 3-phospho-D glyceroyl phosphate. The catalytic reaction begins with the reactants of D-glyceraldehyde-3-phosphate, NAD+, and phosphate. This reaction then proceeds with the products of (2R)-3- phospho-D glyceroyl phosphate, H ion, and NADH. This reaction then proceeds in the glycolysis pathway and creates pyruvate from D-glyceraldehyde-3-phosphate. Glyceraldehyde-3-Phosphate dehydrogenase has a big role in the nucleus. It is a part of many processes such as DNA replication, transcription, RNA transport, and apoptosis. Although is participates in all of those nuclear activities, it is mostly known to initiate apoptosis and transcription of the genes that are known to be involved in the antiapoptotic pathways and cell proliferation. GAPDH also plays a role in regulating of telomere length. Many biochemists have determined that this protein interacts with some types of DNA damages. Examples of them are apurinic/ apyrimidinic sites, nucleotide analogs, and covalent DNA adducts with alkylating agents. This then indicates and confirms that it participates in DNA repair by interacting with repair proteins such as APE1. This protein also plays a part in carbohydrate degradation. It catalyzes an energy yielding step in carbohydrate metabolism. This happens when the nicotinamide adenine dinucleotide and the inorganic phosphate are present. This protein is a tetramer of chains that are identical. Glyceraldehyde-3-Phosphate dehydrogenase is regulated by being inhibited by Fumarate through the formation of S-(2-succinyl) cysteine residues. Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.