Neurotrophin-4 (NFT-4) is a neuronal growth factor that influences nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor.
NFT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation.
Biological Processes
Positive regulation of neurotrophin TRK receptor signaling pathway:
NFT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NFT-4 binding.
Neuron projection morphogenesis:
Generating projection structures of a neuron,.
Ganglion mother cell fate determination, epidermis development, innervation
Nerve invading tissue and coming out
Disease
Relevance
Structural highlights
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↑Mitre M, Mariga A, Chao MV. Neurotrophin signalling: novel insights into mechanisms and pathophysiology. Clin Sci (Lond). 2017 Jan 1;131(1):13-23. doi: 10.1042/CS20160044. PMID:27908981 doi:https://dx.doi.org/10.1042/CS20160044