6ym4 | pdb_00006ym4

Crystal structure of BAY-297 with PIP4K2A

spinqualitylabelsall models 6ym4, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ym4 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, P4Z NonStd Res: PHD Gene: PIP4K2A, PIP5K2, PIP5K2A (HUMAN) Activity: 1-phosphatidylinositol-5-phosphate 4-kinase, with EC number 2.7.1.149 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [PI42A_HUMAN] Precursor B-cell acute lymphoblastic leukemia. Function [PI42A_HUMAN] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

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