6dg3 | pdb_00006dg3

LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with caesium

spinqualitylabelsall models 6dg3, resolution 2.94Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6dg3 is a 12 chain structure with sequence from Lacpl. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CS, PO4 Gene: larE, lp_0109 (LACPL) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [LARE_LACPL] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).

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