7emk | pdb_00007emk

Dendrorhynchus zhejiangensis ferritin

spinqualitylabelsall models 7emk, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7emk is a 1 chain structure with sequence from Dendrorhynchus sinensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, FE, NA, PEG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Ferritin is an important hub of iron metabolism because it stores iron during times of iron overload and releases iron during iron deficiency. Here, we present the first crystal structure of ferritin from the marine invertebrate Dendrorhynchus zhejiangensis with a 2.3 A resolution. D. zhejiangensis ferritin (DzFer) exhibits a common cage-shaped hollow sphere with 24 subunits containing the ferroxidase centers and 3-fold and 4-fold channels. The structure of DzFer shows highly conserved catalytic residues in the ferroxidase center. The metal wire formed by ferrous ions in the 3-fold channel reveals the path that iron ions use to enter and translocate into the ferroxidase site to be oxidized and finally arrive at the nucleation site. However, the electrostatic environment of the channels and pores exhibits significant and extensive variability, suggesting that ferritins execute diverse functions in different environments. Structure determination of ferritin from Dendrorhynchus zhejiangensis.,Huan H, Jiang Q, Wu Y, Qiu X, Lu C, Su C, Zhou J, Li Y, Ming T, Su X Biochem Biophys Res Commun. 2020 Oct 15;531(2):195-202. doi:, 10.1016/j.bbrc.2020.07.069. Epub 2020 Aug 10. PMID:32792196 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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