Structural highlights
6tak is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | GOL, ORO, SO4 |
| Gene: | pyrE, b3642, JW3617 (ECOLI) |
| Activity: | Orotate phosphoribosyltransferase, with EC number 2.4.2.10 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[PYRE_ECOLI] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).[1]
References
- ↑ Henriksen A, Aghajari N, Jensen KF, Gajhede M. A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase. Biochemistry. 1996 Mar 26;35(12):3803-9. PMID:8620002 doi:https://dx.doi.org/10.1021/bi952226y
