7dh6 | pdb_00007dh6

Crystal structure of PLRG1

spinqualitylabelsall models 7dh6, resolution 2.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7dh6 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, NI, SO4 Gene: PLRG1 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PLRG1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Publication Abstract from PubMed PLRG1 is a evolutionarily conserved protein in spliceosome and plays an important role in maintaining the integral part of the splicoeosme and its proper splicing. Here we solved the high resolution crystal structure of the WD40 domain of human PLRG1 by crystallography and compared our crystal structure with the cryo-EM structure of PLRG1 bound with other splicing factors. We found that two loops of the WD40 domain become resolved upon binding to the proteins within the spliceosome. Thus our work characterize the dynamic property of PLRG1 during the spliceosome assembly by presenting its apo structure. Crystal structure of the WD40 domain of human PLRG1.,Wang X, Li Y, Dai H, Xu C Biochem Biophys Res Commun. 2021 Jan 1;534:474-477. doi:, 10.1016/j.bbrc.2020.11.057. Epub 2020 Nov 22. PMID:33239170 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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