7ekt | pdb_00007ekt

human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596

spinqualitylabelsall models 7ekt, resolution 3.02Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7ekt is a 5 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CLR, I33, I34, NAG Gene: CHRNA7, NACHRA7 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [ACHA7_HUMAN] 15q13.3 microdeletion syndrome. Function [ACHA7_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

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