Eukaryotic initiation factor

spinqualitylabelsall models Human initiation factor EIF4E complex with 7-methyl GPPPA 1ipb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Eukaryotic initiation factors or Eukaryotic translation initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. EIF1 is implicated in the stringency of start codon selection. EIF2 binds GTP and Met-tRNA and transfers Met-tRNA to the ribosomal 40S subunit. EIF3 attaches to the 5'-terminal regions mRNA and scan along it to the initiation codon. EIF4 recognizes the m7GpppN cap structure at the 5'-terminal of mRNA. For details see C-terminal portion of human eIF4GI. EIF5 is implicated in the stringency of start codon selection. EIF6 is involved in maturation and/or export from the nucleus of the 60S ribosomal subunit. Disease Overexpression of individual subunits of eIF3 may cause malignant transformation . Overexpression of eIF4g is implicated in breast cancer. Structural insights EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE (7-methyl GPPPA) binding site. Water molecules shown as red spheres. 3D structures of eukaryotic initiation factor Eukaryotic initiation factor 3D structures

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