Factor IX 3D structures

3D structures of factor IX

Updated on 22-July-2021

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• Factor IX; Domains – GLA 1-47; EGF-like 92-130; heavy 227-461; light 133-185
  • 1mgx, 1cfi, 1cfh - hIX GLA domain – human – NMR
    
  • 1edm, 5vyg – hIX EGF-like domain
    
  • 1ixa - hIX EGF-like domain - NMR
    
  • 6mv4 - hIXa light+heavy chain
    
  • 1pfx – pIXa 8-147,183-409 - pig
    
• Factor IX protein complexes
  • 7ahu, 7ahv - hIXa light+heavy chain + antibody
    
  • 3kcg - hIXa light+heavy chains + antithrombin-III+ pentasaccharide
    
  • 1nl0 – hIX GLA domain + anti-factor IX antibody
    
  • 4wm0 – hIX EGF-like domain + xyloside gxylosyltransferase + glucopyranose derivative
    
  • 4wma – hIX EGF-like domain + xyloside gxylosyltransferase + UDP-glucose
    
  • 4wnh – hIX EGF-like domain + xyloside gxylosyltransferase + UDP-xylose
    
  • 4wmb – hIX EGF-like domain + xyloside gxylosyltransferase + UDP
    
  • 4wmi, 4wmk, 4wn2 – hIX EGF-like domain + xyloside gxylosyltransferase + glucopyranose derivative + UDP
    
  • 5f86 – hIX EGF-like domain + glucosyltransferase
    
  • 5f84 – hIX EGF-like domain + glucosyltransferase + UDP-glucose
    
  • 5f85 – hIX EGFlike domain + glucosyltransferase + UDP
    
  • 6rfk – hIX light+heavy chains + peptide - NMR
    
  • 1j34, 1j35 - bIX GLA domain + IX-binding protein – bovine
    
• Factor IX small molecule complexes
  • 3lc3, 3lc5 – hIXa light+heavy chain + benzothiophene inhibitor
    
  • 6x5j, 6x5l - hIXa light+heavy chain + pyrimidine derivative inhibitor
    
  • 6x5p - hIXa light+heavy chain (mutant) + pyrimidine derivative inhibitor
    
  • 5vgy - hIXa EGF-like domain + trisaccharide
    
  • 2wph, 2wpi, 2wpj, 2wpk, 2wpl - hIXa light+heavy chains (mutant) + FPR-chloromethyl ketone
    
  • 2wpm - hIXa light+heavy chains (mutant) + EGR-chloromethyl ketone
    
  • 1rfn - hIXa light+heavy chains EGF2-catalytic domain + inhibitor
    
  • 4yzu, 4z0k, 5tno – hIX peptidase S1 and EGF-like 2 domains + inhibitor
    
  • 4zae, 5egm, 5jb8, 5jb9, 5jba, 5jbb, 5jbc, 5tnt – hIX peptidase S1 and EGF-like 2 domains (mutant) + inhibitor
    
  • 1x7a - pIXa light+heavy chains + inhibitor
    

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Michal Harel