7lj9 | pdb_00007lj9

Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate

spinqualitylabelsall models 7lj9, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7lj9 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACO, OAA Related: 6ui9 Gene: ACLY (HUMAN) Activity: ATP citrate synthase, with EC number 2.3.3.8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Publication Abstract from PubMed An amendment to this paper has been published and can be accessed via a link at the top of the paper. Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase.,Wei X, Schultz K, Bazilevsky GA, Vogt A, Marmorstein R Nat Struct Mol Biol. 2020 May;27(5):511-513. doi: 10.1038/s41594-020-0421-9. PMID:32242119 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also ATP-citrate synthase 3D structures

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