7dqk | pdb_00007dqk

A nicotine MATE transporter, Nicotiana tabacum MATE2 (NtMATE2)

spinqualitylabelsall models 7dqk, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7dqk is a 2 chain structure with sequence from American tobacco. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, OLC, PEG, PO4 Gene: NtMATE2, LOC107807968 (American tobacco) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A transporter of the multidrug and toxic compound extrusion (MATE) family, Nicotiana tabacum MATE2 (NtMATE2) is located in the vacuole membrane of the tobacco plant root and is involved in the transportation of nicotine, a secondary or specialized metabolic compound in Solanaceae. Here, we report the crystal structures of NtMATE2 in its outward-facing forms. The overall structure has a bilobate V-shape with pseudo-symmetrical assembly of the N- and C-lobes. In one crystal structure, the C-lobe cavity of NtMATE2 interacts with an unidentified molecule that may partially mimic a substrate. In addition, NtMATE2-specific conformational transitions imply that an unprecedented movement of the transmembrane alpha-helix 7 (TM7) is related to the release of the substrate into the vacuolar lumen. Crystal structures of a nicotine MATE transporter provide insight into its mechanism of substrate transport.,Tanaka Y, Iwaki S, Sasaki A, Tsukazaki T FEBS Lett. 2021 May 29. doi: 10.1002/1873-3468.14136. PMID:34050946 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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