Types of ligands

spinqualitylabelsall models Human CXCR4 receptor with cyclic peptide ligand (antagonist) CVX15 (PDB code 3oe0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Under construction! In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. Ligands include: Substrates AChE inhibitors and substrates Drug Metabolism by CYP450 Enzymes Malarial Dihydrofolate Reductase as Drug Target In a substrate reduction therapy a small molecule inhibitor (Zavesca™) is used to inhibit the synthesis of the accumulated glucosylceramide. Inhibitors AChE inhibitors and substrates Drug Metabolism by CYP450 Enzymes In a substrate reduction therapy a small molecule inhibitor (Zavesca™) is used to inhibit the synthesis of the accumulated glucosylceramide. Activators Signaling lipids Neurotransmitters A ligand that can bind to and alter the function of the receptor that triggers a physiological response is called a receptor agonist. The synthetic analogue (20S,23S)-epoxymethano-1alpha,25-dihydroxyvitamin D(3) (2a) acts as a 1alpha,25(OH)(2)D(3) superagonist of Vitamin D on Vitamin D receptor and exhibits both antiproliferative and prodifferentiating properties in vitro. Agonist inositol hexakisphosphate binding site in Transport inhibitor response 1 (3c6o). Water molecules are shown as red spheres. Structure of human Bile acid receptor ligand-binding domain (deeppink) complex with non-steroidal agonist, nuclear receptor coactivator 1 peptide (cyan) and sulfate ions (PDB entry 3ruu). Ligands that bind to a receptor but fail to activate the physiological response are receptor antagonists.

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