1s2r | pdb_00001s2r

A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2

spinqualitylabelsall models 1s2r, resolution 1.53Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1s2r is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SPM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA. High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2.,Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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