6z5y

Structure of a novel LPMO from Phytophthora infestans

spinqualitylabelsall models 6z5y, resolution 1.01Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6z5y is a 2 chain structure with sequence from Phyit. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CU, PGE Gene: PITG_04949 (PHYIT) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The oomycete Phytophthora infestans is a damaging crop pathogen and a model organism to study plant-pathogen interactions. We report the discovery of a family of copper-dependent lytic polysaccharide monooxygenases (LPMOs) in plant pathogenic oomycetes and its role in plant infection by P. infestans We show that LPMO-encoding genes are up-regulated early during infection and that the secreted enzymes oxidatively cleave the backbone of pectin, a charged polysaccharide in the plant cell wall. The crystal structure of the most abundant of these LPMOs sheds light on its ability to recognize and degrade pectin, and silencing the encoding gene in P. infestans inhibits infection of potato, indicating a role in host penetration. The identification of LPMOs as virulence factors in pathogenic oomycetes opens up opportunities in crop protection and food security. Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes.,Sabbadin F, Urresti S, Henrissat B, Avrova AO, Welsh LRJ, Lindley PJ, Csukai M, Squires JN, Walton PH, Davies GJ, Bruce NC, Whisson SC, McQueen-Mason SJ Science. 2021 Aug 13;373(6556):774-779. doi: 10.1126/science.abj1342. PMID:34385392 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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