1uyj | pdb_00001uyj

Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin

spinqualitylabelsall models 1uyj, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1uyj is a 3 chain structure with sequence from Clostridium perfringens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: U1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Epsilon-toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of epsilon-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation. Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.,Cole AR, Gibert M, Popoff M, Moss DS, Titball RW, Basak AK Nat Struct Mol Biol. 2004 Aug;11(8):797-8. Epub 2004 Jul 18. PMID:15258571 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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