3jsk | pdb_00003jsk

Thiazole synthase from Neurospora crassa

spinqualitylabelsall models 3jsk, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3jsk is a 16 chain structure with sequence from Chrysonilia crassa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AHZ, FE2 NonStd Res: DHA Related: 2gjc, 1rp0 Gene: NCU06110, NCU06110.1 (Chrysonilia crassa) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [THI4_NEUCR] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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