2i9e | pdb_00002i9e

Structure of Triosephosphate Isomerase of Tenebrio molitor

spinqualitylabelsall models 2i9e, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2i9e is a 4 chain structure with sequence from Tenmo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: TRS Gene: tpi (TENMO) Activity: Triose-phosphate isomerase, with EC number 5.3.1.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A coleopteran triosephosphate isomerase (TIM) from Tenebrio molitor (yellow mealworm beetle) was recombinantly expressed in Escherichia coli and characterized with respect to thermal stability, kinetic parameters and oligomeric state. The enzyme was successfully crystallized and the structure determined by X-ray analysis to 2.0 A resolution. This is the first example of an invertebrate TIM. We compare structural features with known structures of TIMs from microorganisms, plants and vertebrates, and discuss the utility of the Tenebrio TIM sequence, together with several newly sequenced insect TIMs, for molecular phylogenetic analysis. A coleopteran triosephosphate isomerase: X-ray structure and phylogenetic impact of insect sequences.,Knobeloch D, Schmidt A, Scheerer P, Krauss N, Wessner H, Scholz Ch, Kuttner G, von Rintelen T, Wessel A, Hohne W Insect Mol Biol. 2010 Feb;19(1):35-48. Epub 2009 Oct 22. PMID:19849721 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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