1z58 | pdb_00001z58

Crystal structure of a complex of the ribosome large subunit with rapamycin

spinqualitylabelsall models 1z58, resolution 3.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1z58 is a 1 chain structure with sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: RAP Related: 1ond, 1p9x, 1nkw Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins. A crevice adjoining the ribosome tunnel: hints for cotranslational folding.,Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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