| Function
NAD kinase or ATP-dependent NAD kinase (NADK) catalyzes the conversion of ATP and NAD to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism[1]. See NAD and NAD(P)H.
Structural highlights
NADP is bound to NADK in a cleft between the N and C-terminal domains in the dimer interface[2]. Water molecules are shown as red spheres.
- ↑ Ohashi K, Kawai S, Murata K. Identification and characterization of a human mitochondrial NAD kinase. Nat Commun. 2012;3:1248. doi: 10.1038/ncomms2262. PMID:23212377 doi:https://dx.doi.org/10.1038/ncomms2262
- ↑ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:16242716 doi:10.1016/j.jmb.2005.09.026
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3D structures of NAD kinase
Updated on 15-November-2021
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- NAD kinase
- NAD – NADK – human
- NAD, NAD(P)H – MtNADK – Mycobacterium tuberculosis
- 1y3h – MtNADK (mutant)
- 1yt5 – NADK – Thermotoga maritima
- 2i1w – LmNADK – Listeria monocytogenes
- 5ejf, 5ejg, 5ejh – LmNADK (mutant)
- 4hao – NADK – Yersinia pestis
- 3pfn – NADK – human
- NAD kinase complex
- 1y3i – MtNADK + NAD
- 1z0s – AfNADK + ATP + PPi – Archaeoglobus fulgidus
- 1z0u – AfNADK + NADP
- 1z0z – AfNADK + NAD
- 2i29 – LmNADK + NAD
- 2i2a – LmNADK + NADP
- 2i2b, 2i2c, 2i2d, 4dy6, 3v7u, 3v7w, 3v7y, 3v80, 3v8m, 3v7n, 3v7p, 5dhp, 5dhq, 5dhr, 5dhs, 5dht, 5dhu – LmNADK + adenosine derivative inhibitor
- 2q5f, 3v8q, 3v8r – LmNADK (mutant) + adenosine derivative
- 6rbo, 6rbp, 6rbq, 6rbr, 6rbs, 6rbt, 6rbu, 6rbv, 6rbw, 6rbx, 6rby, 6rbz, 6rc0, 6rc1, 6rc2, 6rc3, 6rc4, 6rc5, 6rc6, 6rr2 – LmNADK + adenine derivative
- 6rg6, 6rg7, 6rg8, 6rg8, 6rg9, 6rga, 6rgb, 6rgc, 6rgd, 6rge, 6rgf – LmNADK + inhibitor
- 2i2f – LmNADK (mutant) + NAD + Pi
- 5eji – LmNADK (mutant) + NADP + PPi
References
