2afv | pdb_00002afv

The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

spinqualitylabelsall models 2afv, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2afv is a 2 chain structure with sequence from "leptospira_icteroides"_noguchi_1919 "leptospira icteroides" noguchi 1919. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, P33, P6G Related: 2afr Activity: Precorrin-8X methylmutase, with EC number 5.4.99.61 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12. The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis.,Xue Y, Wei Z, Li X, Gong W J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:16427313 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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