2xsn | pdb_00002xsn

Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain

spinqualitylabelsall models 2xsn, resolution 2.68Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2xsn is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Activity: Tyrosine 3-monooxygenase, with EC number 1.14.16.2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [TY3H_HUMAN] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry. May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls. Function [TY3H_HUMAN] Plays an important role in the physiology of adrenergic neurons. See Also Hydroxylases 3D structures Monooxygenase 3D structures

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