Neuropilin

spinqualitylabelsall models Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) 2qqm Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A. NRP-2 has high affinity for semaphorin-3F. Relevance NRP are highly expressed in human neoplasms. Structural highlights NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region. Ca coordination site. Water molecule are shown as red sphere.

3D Structures of Neuropilin

Updated on 22-November-2021

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• NRP-1
  • 1kex, 2qqi – hNRP-1 B1 domain – human
    
  • 4rn5 – hNRP-1 B1 domain
    
  • 5l73 – hNRP-1 MAM domain
    
  • 2qqm - hNRP-1 A2+B1+B2 domains
    
  • 4deq - hNRP-1 B1 domain + VEGF-A heparin-binding domain
    
  • 6tkk - hNRP-1 B1 domain + VEGF-A peptide
    
  • 7jcc - hNRP-1 B1 domain + SARS-CoV-2 peptide
    
  • 2qqn - hNRP-1 B1 domain + VEGF-blocking antibody
  • 5c7g – hNRP-1 B1 domain + bicine
    
  • 5ijr, 5iyy, 5j1x, 5jgi, 5jgq, 5jhk – hNRP-1 B1 domain + arginine derivative
    
  • 3i97, 6fmc, 6fmf - hNRP-1 B1 domains + inhibitor
  • 2orx – rNRP-1 B domains – rat
  • 2orz – rNRP-1 B domains + tuftsin peptide
    
  • 4gz9 - mNRP-1 – mouse
    
  • 4gza - mNRP-1 + plexin A2 + semaphorin 3A
    
  • 7m0r – mNRP-1 + Semaphorin 3A + plexin A4 – Cryo EM
    
• NRP-2; Domains - CUB 27-145; A2 145-275; B1 275-430; B2 431-595
  • 4qdq, 4qds, 2qqj - hNRP-2 B1+B2 domains
    
  • 5dq0 – hNRP-2 B1 domain
    
  • 4qdr - hNRP-2 B1+B2 domain (mutant)
    
  • 2qqo - hNRP-2 A2+B1+B2 domains

• • 2qqk, 2qql - hNRP-2 A2+B1+B2 domains + semaphorin-blocking antibody
    
  • 5dn2, 6tdb, 6tjt – hNRP-2 B1 domain + VEGF-A C terminal
    
  • 6gh8 – hNRP-2 CUB domain 1 + Gp1
    
  • 7m22 – mNRP-2 + cytomegalovirus – Cryo EM
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman